Zinc And Liver Disease

Zinc And Liver Disease

Zinc is an essential trace mineral that plays a crucial role in many physiological processes, including liver function. 

Zinc deficiency is commonly observed in individuals with chronic liver disease, and supplementation may be considered in some cases. Some research suggests that zinc supplementation in individuals with liver disease may have potential benefits, such as improved liver function, reduced liver damage, and enhanced immune system response.

Is Zinc Good For Your Liver?

Zinc is important for overall health, including liver health, the evidence regarding its specific benefits for the liver is still being studied and further research is needed to establish a definitive link between zinc and liver health. It is worth noting that excessive zinc supplementation can have adverse effects, and zinc should be consumed in appropriate amounts.


1. Antioxidant properties

Zinc acts as an antioxidant, helping to protect liver cells from oxidative stress and damage caused by free radicals. 

2. Detoxification support 

Zinc is involved in various liver detoxification pathways, assisting in the breakdown and elimination of toxins from the body. 

3. Immune system support:

Zinc plays a vital role in maintaining proper immune function, which is important for liver health, as the liver is involved in immune responses and inflammation regulation. 

4. Liver regeneration

Zinc is believed to promote liver cell regeneration and aid in the healing of liver tissue damaged by injury or certain liver diseases.

It is worth noting that while zinc is an important mineral for overall health, including liver health, it should be consumed in appropriate amounts. Excessive zinc supplementation can have adverse effects, so it is advisable to consult with a healthcare professional before starting any new supplements or significantly increasing your zinc intake. They can help determine the proper dosage based on your individual needs and health status.

Zinc Deficiency And Chronic Liver Disease

Zinc deficiency can be commonly observed in individuals with chronic liver disease. Chronic liver disease can impair zinc absorption, increase zinc losses, and affect zinc distribution in the body. 

This, coupled with poor dietary intake, can contribute to lower zinc levels in these individuals. Zinc deficiency in chronic liver disease patients is associated with several adverse effects. It can lead to: 

  • impaired immune function
  • decreased wound healing 
  • increased risk of infections
  • altered taste sensation. 

Additionally, zinc deficiency may exacerbate liver damage, contribute to liver fibrosis, and impact liver regeneration. In some cases, zinc supplementation may be considered as part of the treatment for chronic liver disease patients with zinc deficiency. 

However, the benefits and optimal dosage of zinc supplementation in these individuals are still being studied. It is important for individuals with chronic liver disease to consult with their healthcare providers for proper assessment, guidance, and recommendations regarding zinc and other nutritional requirements.

When Should You Take Zinc for Liver Health?

When to take zinc for liver health may vary depending on individual circumstances and healthcare provider recommendations. Here are a few general considerations: 

Consult with a healthcare professional 

Before starting any new supplement regimen, including zinc for liver health, it is important to consult with a healthcare professional. They can evaluate your specific needs, and underlying health conditions, and determine if zinc supplementation is appropriate for you. 

Follow recommended dosage

If your healthcare professional recommends zinc supplementation for liver health, be sure to follow their instructions regarding dosage and timing. Zinc supplements are typically taken orally, and the dosage can vary based on individual needs. 

Take with or without food

Zinc supplements can generally be taken with or without food. However, some people may experience digestive discomfort when taking zinc on an empty stomach. If this occurs, taking zinc with a meal can help minimize such issues. 

Avoid interactions

Certain medications and dietary components can interfere with zinc absorption or utilization

To ensure the best results, it is advisable to follow any instructions provided by your healthcare professional, particularly if you are taking other medications or supplements. Remember, individual needs and conditions may vary, so it’s important to follow the guidance of a healthcare professional to determine the most appropriate timing and dosage of zinc supplementation for your liver health.

If you enjoyed this article, you may also want to read this article on 8 Best Teas for a Healthy Liver.

*This information is not intended to serve as a substitute for professional medical or dietary advice tailored to individual needs.

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Dr. Kimberly Langdon

Kimberly Langdon

Dr. Kimberly Langdon has been an MD for 31 years, board-certified obstetrician/gynecologist with 19-years of clinical experience. She graduated from The Ohio State University College of Medicine, earning Honors in many rotations. She then completed her OB/GYN residency program at The Ohio State University Medical Center, earning first-place accolades for her Senior Research Project and Score of 98th percentile on a National Proficiency Test.

During her clinical career, she delivered over 2000 babies and specialized in minimally invasive procedures, menopause, endometriosis, menstrual disorders, and polycystic ovarian syndrome. After retiring from clinical practice, she founded a medical device company to commercialize her two patented and four patent-pending medical devices for both life-threatening and non-life-threatening infections.

Kimberly Langdon M.D.

Founder and Chief Scientific Officer, Coologics, 2010-present
The Ohio State University College of Medicine, Doctor of Medicine 1987-1991
The Ohio State University Hospital Department of Obstetrics and Gynecology Residency Program 1991-1995
Private practice 1995-2010

Po-Chang Hsu

Po-Chang Hsu

Po-Chang Hsu, M.D., received his medical doctorate from Tufts University School of Medicine in Boston. During his medical school training, Dr. Hsu worked with various patients, including adult and pediatric patients with acute and chronic conditions. Dr. Hsu’s interests include neurology, psychiatry, pediatrics, and sleep medicine.

Before medical school, Dr. Hsu finished a master’s degree at Harvard University and wrote a thesis on neuroimaging in schizophrenia patients at Brigham and Women’s Hospital, a Harvard Medical School-affiliated hospital. Dr. Hsu was also a part of the 2008 NASA Phoenix Lander Mission team, which sent a robotic spacecraft to the North polar region of Mars. Dr. Hsu also had research experience on neuroimaging in neonates at Boston Children’s Hospital, another Harvard Medical School-affiliated Hospital.

Since graduating from medical school, Dr. Hsu has worked as a full-time medical writer and consultant. In addition, he has experience writing and ghostwriting books and articles for physicians and health technology start-up companies. Dr. Hsu believes good communication between healthcare providers and patients creates the best results.


-Peer Reviewed Journal Article:
Kounaves, S.P., Hecht, M.H., West, S.J., Morookian, J.-M., Young, S.M.M., Quinn, R., Grunthaner, P., Wen, X., Weilert, M., Cable, C.A., Fisher, A., Gospodinova, K., Kapit, J., Stroble, S., Hsu, P.-C., Clark, B.C., Ming, D.W. and Smith, P.H. The MECA wet chemistry laboratory on the 2007 phoenix mars scout Lander. Journal of Geophysical Research. 2009, Mar; 114(E3): 10.1029/2008je003084.

-Poster Presentation:
2011 Harvard Psychiatry Mysell Poster Session; Boston, MA
Hsu, P.C., Rathi, Y., Eckbo, R., Nestor, P., Niznikiewicz, M., Thompson, E., Kubicki, M., Shenton, M.E. (March, 2011). Two-Tensor Diffusion Tensor Imaging of Acoustic Radiations in Schizophrenia

Dr. Nicolette Natale

Nicolette Natale

Dr. Nicolette Natale is a physician, with a background in Psychology, General Medicine, and English Literature, combining her expertise to provide readers with the most accurate, easy-to-understand, and comprehensive information regarding healthcare. She received her Doctorate in Osteopathic Medicine from Nova Southeastern University, and her bachelor’s in English Literature and Psychology from the University of Miami. Dr. Natale seeks to empower individuals with knowledge, fostering a greater understanding of holistic health and encouraging a proactive approach to well-being