Can Collagen Improve Gut Health?

Can Collagen Improve Gut Health?

The digestive tract, often known as the gut, is a complicated, critical organ that is in charge of breaking down food into nutrients, absorbing needed nutrients, and removing waste. A healthy gut is essential for general health since it is involved in immune function, metabolism, and mental wellness. 

Collagen, a protein present in abundance in the body’s connective tissues, has lately attracted attention for its possible advantages in gut health promotion.

We’ll look into the link between collagen and gut health, looking at the science behind its possible advantages as well as how to include collagen in your diet for a healthy gut.

What is Collagen?

Understanding collagen is essential before looking into its possible implications on gut health. Collagen is the most abundant protein in the human body, making up around 25% of total protein content. A key component of connective tissues such as tendons, ligaments, skin, and bones. It acts as a scaffold, supporting and preserving numerous biological components.

Collagen is made up of three major amino acids: glycine, proline, and hydroxyproline.

Is Collagen Good for Gut Health?


The short answer is yes. Collagen is beneficial to intestinal health. Collagen has several key advantages for your stomach, including aiding digestion, repairing the gut lining, and healing leaky gut and IBS.

Collagen peptides, also known as hydrolyzed collagen, are protein that is easily digested, pure, and accessible. Unhealthy intestines frequently fail to absorb nutrients from dietary sources, particularly proteins. Collagen peptides have already been degraded to their simplest molecular structure and are ready for usage by the body.

Benefits of Collagen in Gut Health

Repair and Strengthen Gut Lining

Collagen helps to rebuild and strengthen the lining of our digestive tract because it includes amino acids that are necessary for its healing, notably glycine and glutamine. In fact, studies have demonstrated that collagen peptides can help to enhance gut barrier function and tight junctions. 

A 2020 animal research discovered an intriguing link between a collagen-rich diet and changed microbiota with enhanced short-chain fatty acid synthesis.

Can Help in the Treatment of Leaky Gut Syndrome

Leaky gut syndrome, in which the integrity of the intestinal barrier is disrupted, is linked to a variety of health problems. Collagen’s capacity to thicken the gut lining may help to alleviate the symptoms of leaky gut.

Toxins, germs, and food particles may enter the circulation if the stomach becomes ‘leaky,’ causing inflammation and potentially leading to a variety of health concerns. The amino acid glutamine, which is rich in collagen, has been demonstrated to lower intestinal permeability and hence play an important role in the repair of leaky gut syndrome.

Can Reduce Gut Inflammation

Gut inflammation is a typical source of worry. Collagen’s anti-inflammatory qualities, which are attributable to its amino acid makeup, may aid in the reduction of inflammation, so producing a more suitable environment for digestion processes.

Glycine, an amino acid present in collagen, has anti-inflammatory effects that can help reduce inflammation in the stomach. Individuals suffering from inflammatory bowel disease (IBD) or other inflammation-related gastrointestinal disorders would benefit the most from this feature.

Helps Balance the Gut Microbiome

A healthy gut microbiota is essential for general health. It is a diverse colony of bacteria that lives in our digestive system and plays an important role in many areas of human health. 

A healthy microbiome is essential for digestion, food absorption, and immune function. The ability of collagen to sustain a healthy microbial ecology in the gut can improve digestion and immunological function.

Aids Digestion and Nutrient Absorption

When we have digestive problems, such as leaky gut, we are more likely to have poor nutrient absorption because nutrients that would normally be effectively digested and absorbed in a healthy gut might escape through the intestinal lining. However, because collagen serves to promote gut wall integrity, we may assist in reducing nutrient loss owing to decreased gut function by increasing our collagen intake.

When broken down during digestion, collagen’s gel-like structure may function as a calming material for the digestive tract. It may also improve nutrient absorption, contributing to overall digestive efficiency.

Good Collagen Sources


Collagen may be derived from a variety of sources, including:

  • Bone broth
  • Collagen supplements (powders, capsules)
  • Chicken skin
  • Scales and skin of fish
  • Pork skin

Supplements containing collagen:

Collagen supplements come in a variety of formats, including powders, capsules, and liquids. Hydrolyzed collagen, a broken-down type of collagen, is easier for the body to absorb.

What Should You Eat for a Healthier Gut?

Maintaining a good gut requires not just including healthful foods, but also being aware of those that may contribute to digestive problems. Here’s a list of gut-friendly meals and ones to avoid:

Gut-Friendly Foods:


Fiber-Rich Fruits and Vegetables: Berries, apples, bananas, broccoli, spinach, carrots.

  • High-fiber fruits and vegetables promote gut motility and provide essential nutrients for the growth of beneficial gut bacteria.

Probiotic-Rich Foods: Yogurt, kefir, sauerkraut, kimchi, miso, tempeh.

  • Probiotics introduce beneficial bacteria into the gut, promoting a balanced microbiome and supporting digestive health.

Prebiotic-Rich Foods: Garlic, onions, leeks, asparagus, bananas, oats.

  • Prebiotics are non-digestible fibers that nourish the existing beneficial bacteria in the gut, fostering a healthy microbial environment.

Whole Grains: Quinoa, brown rice, whole wheat, oats.

  • Whole grains provide fiber and nutrients that contribute to overall gut health and aid in digestion.

Lean Proteins: Chicken, turkey, fish, eggs, tofu.

  • Lean protein sources support muscle health and provide essential amino acids for various bodily functions, including gut repair.

Healthy Fats: Avocado, olive oil, nuts, seeds, fatty fish (salmon, mackerel).

  • Healthy fats contribute to a well-functioning digestive system and support the absorption of fat-soluble vitamins.

Foods to Avoid:

Highly Processed Foods: Processed foods frequently include chemicals and preservatives that can disturb gut flora balance and lead to inflammation.

Added Sugars: Excess sugar consumption can feed undesirable bacteria in the stomach and lead to inflammation. Keeping additional sugars to a minimum promotes intestinal health.

Artificial Sweeteners: Some artificial sweeteners have been shown to change the makeup of gut flora, potentially affecting digestive health.

High-Fat and Fried Foods: While healthy fats are helpful, eating too many high-fat and fried meals can cause digestive discomfort and may contribute to inflammation.

Excessive Red Meat: Excessive red meat consumption has been linked to alterations in gut flora and increased inflammation. Moderation is essential.

Alcohol: Excessive alcohol use can disturb the balance of gut flora and lead to digestive tract inflammation.


The link between collagen and gut health is a fascinating subject to pursue. The possible advantages, ranging from gut lining fortification to supporting a healthy microbiota, highlight collagen’s multifaceted function in digestive well-being. 

As research in this sector progresses, combining collagen-rich foods or supplements with a gut-friendly diet offers promise for anyone looking to nurture their digestive environment.

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Dr. Kimberly Langdon

Kimberly Langdon

Dr. Kimberly Langdon has been an MD for 31 years, board-certified obstetrician/gynecologist with 19-years of clinical experience. She graduated from The Ohio State University College of Medicine, earning Honors in many rotations. She then completed her OB/GYN residency program at The Ohio State University Medical Center, earning first-place accolades for her Senior Research Project and Score of 98th percentile on a National Proficiency Test.

During her clinical career, she delivered over 2000 babies and specialized in minimally invasive procedures, menopause, endometriosis, menstrual disorders, and polycystic ovarian syndrome. After retiring from clinical practice, she founded a medical device company to commercialize her two patented and four patent-pending medical devices for both life-threatening and non-life-threatening infections.

Kimberly Langdon M.D.

Founder and Chief Scientific Officer, Coologics, 2010-present
The Ohio State University College of Medicine, Doctor of Medicine 1987-1991
The Ohio State University Hospital Department of Obstetrics and Gynecology Residency Program 1991-1995
Private practice 1995-2010

Po-Chang Hsu

Po-Chang Hsu

Po-Chang Hsu, M.D., received his medical doctorate from Tufts University School of Medicine in Boston. During his medical school training, Dr. Hsu worked with various patients, including adult and pediatric patients with acute and chronic conditions. Dr. Hsu’s interests include neurology, psychiatry, pediatrics, and sleep medicine.

Before medical school, Dr. Hsu finished a master’s degree at Harvard University and wrote a thesis on neuroimaging in schizophrenia patients at Brigham and Women’s Hospital, a Harvard Medical School-affiliated hospital. Dr. Hsu was also a part of the 2008 NASA Phoenix Lander Mission team, which sent a robotic spacecraft to the North polar region of Mars. Dr. Hsu also had research experience on neuroimaging in neonates at Boston Children’s Hospital, another Harvard Medical School-affiliated Hospital.

Since graduating from medical school, Dr. Hsu has worked as a full-time medical writer and consultant. In addition, he has experience writing and ghostwriting books and articles for physicians and health technology start-up companies. Dr. Hsu believes good communication between healthcare providers and patients creates the best results.


-Peer Reviewed Journal Article:
Kounaves, S.P., Hecht, M.H., West, S.J., Morookian, J.-M., Young, S.M.M., Quinn, R., Grunthaner, P., Wen, X., Weilert, M., Cable, C.A., Fisher, A., Gospodinova, K., Kapit, J., Stroble, S., Hsu, P.-C., Clark, B.C., Ming, D.W. and Smith, P.H. The MECA wet chemistry laboratory on the 2007 phoenix mars scout Lander. Journal of Geophysical Research. 2009, Mar; 114(E3): 10.1029/2008je003084.

-Poster Presentation:
2011 Harvard Psychiatry Mysell Poster Session; Boston, MA
Hsu, P.C., Rathi, Y., Eckbo, R., Nestor, P., Niznikiewicz, M., Thompson, E., Kubicki, M., Shenton, M.E. (March, 2011). Two-Tensor Diffusion Tensor Imaging of Acoustic Radiations in Schizophrenia

Dr. Nicolette Natale

Nicolette Natale

Dr. Nicolette Natale is a physician, with a background in Psychology, General Medicine, and English Literature, combining her expertise to provide readers with the most accurate, easy-to-understand, and comprehensive information regarding healthcare. She received her Doctorate in Osteopathic Medicine from Nova Southeastern University, and her bachelor’s in English Literature and Psychology from the University of Miami. Dr. Natale seeks to empower individuals with knowledge, fostering a greater understanding of holistic health and encouraging a proactive approach to well-being